1. Challenge No. RESEARCH DESIGN AND METHODS The Dapagliflozin Effect on Cardiovascular Events (DECLARE)–TIMI 58 assessed cardiac and renal outcomes of dapagliflozin versus placebo in patients with type 2 diabetes. INTRODUCTION. As you get older, your … 5: Adverse Effects The elderly are at increased risk of adverse drug reactions (ADR) increased exposure due to changes in drug pharmacokinetics increased sensitivity of some organs to drugs polypharmacy Antibacterials a frequent cause of ER visits due to ADRs, esp. Gillick MRSerrell NAGillick LS Adverse consequences of hospitalization in the elderly. Complications that occur with increasing frequency in the elderly contribute to adverse reactions of substance misuse. CONCLUSION: Medical adverse events should be monitored in every elderly hospitalized patient because there is no risk profile for susceptible patients, and the consequences of adverse events are serious, sometimes leading to longer hospital stays or even death. Over half (54%) experienced some degree of acute confusion during their hospitalization. The most common mechanism of injury in the elderly population is falling. The COVID-19 pandemic has recently been the cause of a global public health emergency. ACSCs can be acute (bacterial pneumonia, cellulitis, urinary tract infection, pressure ulcer) or chronic (diabetes, COPD, asthma, hypertension, heart failure). 12, No. There was a 24% incidence of pressure ulcers and a 2% incidence of adverse reactions to medications. Bourgeois et al. During the 8-month study, 240 episodes occurred in 198 patients. For many years, the negative functional consequences of prolonged hospitalization have been well recognized. Using hospital electronic medical records (EMR), we evaluated the prescriptions of outpatients aged 65 years or older. ... are commonly prescribed to older adults with sleep-related complaints. Many elderly patients are susceptible to other complications not directly related to the illness or injury for which they were hospitalized or the specific treatment of the problem. The estimated proportion of participants aged 65 and older was 42.5% and the estimated proportion aged 75 and older was 12.3%. 2010 Oct 1;33(10):853-64. doi: 10.2165/11536800-000000000-00000. This is a mental dysfunction signified by a sudden onslaught of confusion, inattention, and disorientation. Population aging has resulted in an increase in the number of hospitalized elderly people. J of Gerontol April 2013 68(4) 13 • We interviewed 315 consecutive elderly patients admitted to an acute care hospital to determine the percentage of elderly hospital admissions due to noncompliance with medication regimens or adverse drug reactions, their causes, consequences, and predictors. OBJECTIVE Data regarding the effects of sodium–glucose cotransporter 2 inhibitors in the elderly (age ≥65 years) and very elderly (age ≥75 years) are limited. Objective: To investigate the association between potentially inappropriate medicine (PIM) use, defined using the American Geriatric Society (AGS) 2012 Beers criteria, and the risk of hospitalization or emergency department (ED) visits in elderly patients, and to examine the most frequently used PIMs among patients with adverse outcomes. Adverse consequences of hospitalization in the elderly. Therefore, the aim of this study was to investigate whether polypharmacy has a prolonging effect on hospitalization. There is a lack of evidence that multidrug use triggers adverse events. A 2012 study from Neurology suggested that in elderly patients, cognitive declines more than double after a hospital stay, affecting patients' thinking and memory skills. The observed-to-expected ratio is multiplied by the hospitalization rate across all health plans to produce a risk-standardized rate which allows for national comparison. The researchers studied 64 patients (mean age 74.4 years) for the duration of their hospitalization. 4. Taken together, these data suggest that adverse health consequences attributable to hospitalization extend across the spectrum of age, presenting disease severity, and hospital treatment location. ‘to compare the incidence, preventability, types and consequences of adverse events between elderly patients (of ≥75 years) and those <75 years old in a large NHS hospital’ Two-stage retrospective case record review Surgery, urology, orthopaedics, general medicine, medicine for the elderly, oncology, ENT and ophthalmology 1006 332 (33%) The reported episodes were the untoward consequences of acceptable medical care in diagnosis and therapy. Age Increases Risk for Hospitalization. Polypharmacy can be associated with many adverse effects, especially when it comes to elderly, frail patients. Consequences of substance abuse in the aging and elderly. In 105 patients, hospitalization was either prolonged by an adverse episode or the manifestations were not yet resolved at time of discharge. COVID-19: Impact of Hospitalization and ICU on the Musculoskeletal System It has been evidenced that the hospitalization rates for COVID-19 increase with age and that older adults are at the highest risk of hospital admission [23]. While hospitalization in this population is often necessary, it is difficult to ignore the major risk this entails for the patients. Nature, occurrence and consequences of medication-related adverse events during hospitalization: a retrospective chart review in the Netherlands. It’s one of the more common complications of hospital visits for elderly patients—approximately 20% of all elderly patients, 50% of those in surgery post-op, and a whopping 60% to 85% of patients on ventilation exhibit the signs. Elderly patients with cognitive impairment have a high risk for functional decline during hospitalization… Adverse reactions are common in older adults and often manifest differently than in younger patients. Therefore, the main purpose of this study was to clarify the relationship between the total number of drugs and number of high-risk prescriptions administered to Japanese elderly patients. 3. Fortinsky RH, Covinsky KE, Palmer RM, Landefeld CS. ... the choice of treatment depends on the severity of the condition and the level of functional impairment and varies from hospitalization to outpatient care. hospitalization of older patients over the past decade [1, 5–9]. 1 – 3 Their use has been linked to serious adverse ... but often overlooked issue is that long-term use of benzodiazepines can lead to dependence. The above image shows a distal radius fracture, a common injury after a fall onto an outstretched hand. •Elderly patients with cognitive impairment are more likely to die during hospitalization with a severity-dependent association •67.3% versus 32.7% (p < .001) of patients who died during hospitalization and 54.3% versus 45.7% (p < .001) during follow-up had at least one adverse event Marengoni et al. Loneliness and social isolation in older adults are serious public health risks affecting a significant number of people in the United States and putting them at risk for dementia and other serious medical conditions. PubMed CrossRef Google Scholar. Initiation of Benzodiazepines in the Elderly After Hospitalization. The longer the hospitalization, the greater the effect. Notably in view of their vulnerability due to comorbidities such as cardiovascular diseases, it is www.aging-us.com AGING 2020, Vol. 13 From these trials, 446 (53%) explicitly excluded elderly adults. Those events may trigger prolonged length of hospitalization. Polypharmacy in elderly people is a social issue and has been reported to cause not only drug adverse events, but also falls, dysfunction and cognitive decline. Soc Sci Med 1982;16 (10) 1033- 1038 PubMed Google Scholar Crossref 4. Drug Saf. Khokan C Sikdar, Jeffrey Dowden, Reza Alaghehbandan, Don MacDonald, Peizhong Peter Wang and Veeresh Gadag, Adverse Drug Reactions in Elderly Hospitalized Patients: A 12-Year Population-Based Retrospective Cohort Study, Annals of Pharmacotherapy, 10.1345/aph.1Q529, 46, … In the past decades, many studies considered predictors of institutionalization in the elderly. This paper describes the impact of prolonged immobilization and current pharmacological treatments on muscular metabolism. It is reported that an estimated 35% of ambulatory older adults experience an adverse drug reaction each year, and 29% of these reactions require hospitalization. Soc Sci Med. evaluated the exclusion of elderly adults from 839 randomized trials studying drug interventions for ischemic heart disease. Risk of hypoglycemia, medication adherence, drug-drug interactions, worsened quality of life, increased risk of hospitalization, mortality rate, and health care … The adverse outcomes accompanying institutionalization have confirmed the effort to prevent or delay nursing home placement (NHP). Consequences of Hospitalization 23.3% risk of being unable to return home and require nursing home placement 35% decline in some basic ADL 50% of elderly patients experience some kind of complication related to hospitalization Methods Older adults are at greater risk of requiring hospitalization or dying if they are diagnosed with COVID-19. Elderly patients are far different than their younger counterparts — so much so that some hospitals are treating some of them in separate medical units. 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